blood coagulation

By Targets:	Factor VIII (1) Apoptosis (1) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (1) DNA/RNA Synthesis (1) Endogenous Metabolite (6) Estrogen Receptor/ERR (1) Factor Xa (1) NF-κB (1) Ser/Thr Protease (1) Thrombin (1) Tyrosinase (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (10) Infection (1) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (1)

Targets Recommended: Factor VIII

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99769

Omfiloctocog alfa SCT-800	Factor VIII	Metabolic Disease
Omfiloctocog alfa (SCT-800) is a recombinant factor VIII (FVIII). FVIII is an essential blood coagulation protein and a key component of the fluid phase blood coagulation system. Omfiloctocog alfa can be used for the research of Hemophilia A .

HY-B1508

Vitamin K4 Acetomenaphthone	Endogenous Metabolite Apoptosis	Cardiovascular Disease Cancer
Vitamin K4 is a chemically synthesized Vitamin K which plays an important role in the normal blood coagulation system. Vitamin K4 arrests the cells in S phase and induces apoptosis. Vitamin K4 can be used for the research of cancer, such as prostate cancer and osteosarcoma .

HY-B0665

Fibrin	Others	Cardiovascular Disease Cancer
Fibrin, isolated from bovine blood, is an insoluble protein produced in response to bleeding. Fibrin is the major component of the blood clot and is used for coagulation .

HY-N0684

Vitamin K1 2 Publications Verification Phylloquinone; Phytomenadione	Endogenous Metabolite	Cardiovascular Disease
Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-B2172

Vitamin K	Endogenous Metabolite	Cardiovascular Disease
Vitamin K, the blood-clotting vitamin, is important for the function of numerous proteins within the body, such as the coagulation factors, osteocalcin and matrix-Gla protein.

HY-B1192S

Estradiol benzoate-d3 β-Estradiol 3-benzoate-d₃; 17β-Estradiol 3-benzoate-d₃	Estrogen Receptor/ERR
Estradiol benzoate-d₃ is the deuterium labeled Estradiol benzoate. Estradiol Benzoate (β-Estradiol 3-benzoate), a proagent of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability[1][2][3][4].

HY-N2101

Benzoyloxypaeoniflorin	Tyrosinase NF-κB	Inflammation/Immunology
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a tyrosinase inhibitor against mushroom tyrosinase with IC₅₀ of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation .

HY-114164

Thrombin (MW 37kDa) 4 Publications Verification	Thrombin	Neurological Disease
Thrombin (MW 37kDa) is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins.

HY-N0684S3

Vitamin K1-13C6 Phylloquinone-¹³C₆; Phytomenadione-¹³C₆	Endogenous Metabolite	Cardiovascular Disease
Vitamin K1- ¹³C₆ is the ¹³C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-N0684S1

Vitamin K1-d4 Phylloquinone-d₄; Phytomenadione-d₄	Endogenous Metabolite	Cardiovascular Disease
Vitamin K1-d₄ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1].

HY-N0684S

Vitamin K1-d7	Endogenous Metabolite	Cardiovascular Disease
Vitamin K1-d₇ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1][2].

HY-N0712

Typhaneoside 1 Publications Verification	Autophagy	Cardiovascular Disease Inflammation/Immunology
Typhaneoside, extracted from Typha angustifolia L., Typhaneoside can inhibit the excessive autophagy of hypoxia/reoxygenation cells and increase the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering blood lipid levels, promoting antiatherosclerosis activities, as well as improving immune and coagulation function .

HY-126944

2-Aminobenzanilide 2-Amino-N-phenylbenzamide	Biochemical Assay Reagents	Cancer
2-Aminobenzamide is a neutral and stable compound used as fluorescent tag, numerously in Glycan analysis. 2-aminobenzamide acts as the starting material for several important reactions like Bargellini reaction as an competent ambident nucleophile. Specifically 2-aminobenzamide and its derivatives are used in the blood coagulation cascade .

HY-127034

Antipain dihydrochloride	Ser/Thr Protease DNA/RNA Synthesis	Metabolic Disease Cancer
Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice .

HY-N4314

Scutellarein tetramethyl ether 1 Publications Verification 4',5,6,7-Tetramethoxyflavone	Bacterial	Infection Inflammation/Immunology
Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is a bioactive component of Siam weed extract. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) exhibits anti-inflammatory activity through NF-κB pathway . Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) modulats of bacterial agent resistance via efflux pump inhibition . Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) can enhance blood coagulation .

HY-125856

Milvexian BMS-986177; JNJ-70033093	Factor Xa	Cardiovascular Disease
Milvexian is an orally bioavailable, small-molecule, reversible, direct antagonists of factor Xia, with the K_i of 0.11, 0.38, 0.64, 490, 350 nM for human, rabbit, dog, rat, mouse, respectively. Milvexian shows anti-thrombosis activity in vitro and in vivo, and can be used for thrombus study .

Cat. No.	Product Name

HY-L136

Coagulation and Anti-coagulation Compound Library	965 compounds
Coagulation, also known as clotting, is the process in which blood changes from a liquid to a solid gel to form a blood clot. Thrombin, which is accurately and evenly generated in the injured part of blood vessels, is a key effector enzyme of the blood coagulation system and participates in many important biological processes, such as platelet activation, fibrinogen conversion to fibrin network, coagulation feedback amplification, etc. At the same time, to avoid the accidental formation of thrombus in the body, there is also an anticoagulant mechanism that inhibits blood coagulation. Normal coagulation mechanism represents a balance between the pro-coagulant pathway in the injured site and anti-coagulant pathway beyond it. The blood coagulation system may be out of balance during the perioperative period or critical illness, which may lead to thrombosis or excessive bleeding. Therefore, the physiological study of coagulation balance is an important basis for clinical diagnosis and treatment of the abnormal coagulation process. MCE supplies a unique collection of 965 compounds targeting key proteins in coagulation and anti-coagulation system. MCE Coagulation and Anti-coagulation Compound Library is a useful tool for study the mechanism of coagulation and anticoagulation.

Coagulation and Anti-coagulation Compound Library

965 compounds

Coagulation, also known as clotting, is the process in which blood changes from a liquid to a solid gel to form a blood clot. Thrombin, which is accurately and evenly generated in the injured part of blood vessels, is a key effector enzyme of the blood coagulation system and participates in many important biological processes, such as platelet activation, fibrinogen conversion to fibrin network, coagulation feedback amplification, etc. At the same time, to avoid the accidental formation of thrombus in the body, there is also an anticoagulant mechanism that inhibits blood coagulation.

Normal coagulation mechanism represents a balance between the pro-coagulant pathway in the injured site and anti-coagulant pathway beyond it. The blood coagulation system may be out of balance during the perioperative period or critical illness, which may lead to thrombosis or excessive bleeding. Therefore, the physiological study of coagulation balance is an important basis for clinical diagnosis and treatment of the abnormal coagulation process.

MCE supplies a unique collection of 965 compounds targeting key proteins in coagulation and anti-coagulation system. MCE Coagulation and Anti-coagulation Compound Library is a useful tool for study the mechanism of coagulation and anticoagulation.

Cat. No.	Product Name	Type

HY-126944

2-Aminobenzanilide 2-Amino-N-phenylbenzamide	Biochemical Assay Reagents
2-Aminobenzamide is a neutral and stable compound used as fluorescent tag, numerously in Glycan analysis. 2-aminobenzamide acts as the starting material for several important reactions like Bargellini reaction as an competent ambident nucleophile. Specifically 2-aminobenzamide and its derivatives are used in the blood coagulation cascade .

Cat. No.	Product Name	Target	Research Area

HY-P4908

S-(1,2-Dicarboxyethyl)glutathione

Peptides Cardiovascular Disease

S-(1,2-Dicarboxyethyl)glutathione is a peptide that inhibits blood coagulation and platelet aggregation .

S-(1,2-Dicarboxyethyl)glutathione	Peptides	Cardiovascular Disease
S-(1,2-Dicarboxyethyl)glutathione is a peptide that inhibits blood coagulation and platelet aggregation .

Cat. No.	Product Name	Target	Research Area

HY-P99769

Omfiloctocog alfa SCT-800	Factor VIII	Metabolic Disease
Omfiloctocog alfa (SCT-800) is a recombinant factor VIII (FVIII). FVIII is an essential blood coagulation protein and a key component of the fluid phase blood coagulation system. Omfiloctocog alfa can be used for the research of Hemophilia A .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1508

Vitamin K4 Acetomenaphthone	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
Vitamin K4 is a chemically synthesized Vitamin K which plays an important role in the normal blood coagulation system. Vitamin K4 arrests the cells in S phase and induces apoptosis. Vitamin K4 can be used for the research of cancer, such as prostate cancer and osteosarcoma .

HY-B0665

Fibrin	Cardiovascular Disease Natural Products Animals Source classification Disease Research Fields Cancer	Others
Fibrin, isolated from bovine blood, is an insoluble protein produced in response to bleeding. Fibrin is the major component of the blood clot and is used for coagulation .

HY-N0684

Vitamin K1 2 Publications Verification Phylloquinone; Phytomenadione	Cardiovascular Disease Quinones Human Gut Microbiota Metabolites other families Microorganisms Classification of Application Fields Source classification Plants Endogenous metabolite Naphthalene Quinones Disease Research Fields	Endogenous Metabolite
Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

HY-B2172

Vitamin K	Cardiovascular Disease Natural Products other families Microorganisms Classification of Application Fields Animals Source classification Plants Disease Research Fields	Endogenous Metabolite
Vitamin K, the blood-clotting vitamin, is important for the function of numerous proteins within the body, such as the coagulation factors, osteocalcin and matrix-Gla protein.

HY-N2101

Benzoyloxypaeoniflorin	Other Monoterpenes Monophenols Classification of Application Fields Paeonia lactiflora Pall. Terpenoids Source classification Phenols Plants Paeoniaceae Inflammation/Immunology Disease Research Fields	Tyrosinase NF-κB
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a tyrosinase inhibitor against mushroom tyrosinase with IC₅₀ of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation .

HY-N0712

Typhaneoside 1 Publications Verification	Cardiovascular Disease Flavonols Flavonoids Classification of Application Fields Typhaceae Source classification Typha angustifolia L. Phenols Polyphenols Plants Disease Research Fields	Autophagy
Typhaneoside, extracted from Typha angustifolia L., Typhaneoside can inhibit the excessive autophagy of hypoxia/reoxygenation cells and increase the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering blood lipid levels, promoting antiatherosclerosis activities, as well as improving immune and coagulation function .

HY-N4314

Scutellarein tetramethyl ether 1 Publications Verification 4',5,6,7-Tetramethoxyflavone	Infection Structural Classification Flavonoids Classification of Application Fields Flavones Plants Compositae Inflammation/Immunology Disease Research Fields Genista maderensis (Webb & Berthel.) Lowe	Bacterial
Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is a bioactive component of Siam weed extract. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) exhibits anti-inflammatory activity through NF-κB pathway . Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) modulats of bacterial agent resistance via efflux pump inhibition . Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) can enhance blood coagulation .

Cat. No.	Product Name	Chemical Structure

HY-B1192S

Estradiol benzoate-d3
Estradiol benzoate-d₃ is the deuterium labeled Estradiol benzoate. Estradiol Benzoate (β-Estradiol 3-benzoate), a proagent of estradiol, acts as a steroid sex hormone. It exhibits mild anabolic and metabolic properties, and increases blood coagulability[1][2][3][4].

HY-N0684S3

Vitamin K1-13C6

Vitamin K1- ¹³C₆ is the ¹³C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
HY-N0684S

Vitamin K1-d7

Vitamin K1-d₇ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1][2].
HY-N0684S1

Vitamin K1-d4

Vitamin K1-d₄ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1].

Vitamin K1-13C6
Vitamin K1- ¹³C₆ is the ¹³C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.

Vitamin K1-d7
Vitamin K1-d₇ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1][2].

Vitamin K1-d4
Vitamin K1-d₄ is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1].

Cat. No.	Product Name	Application	Reactivity

HY-P82716

Protein C Antibody (YA2461)

PROC; Vitamin K-dependent protein C; Anticoagulant protein C; Autoprothrombin IIA; blood coagulation factor XIV
WB Human

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